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. 2023 Oct 26;16:6859–6870. doi: 10.2147/IDR.S429001

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© 2023 Mekonnen et al.

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Genes, amino acid substitutions (single nucleotide polymorphism) associated with first line anti-TB drugs, Northwest Ethiopia, 2023.

Notes: The RIF resistance was determined with rpoB gene with eight types of amino acid (aa) substitutions. INH resistance was mediated with katG gene with two aa substitutions. The PZA resistance was conferred with pncA gene with mutations at four sites. Nine mutations at embB gene were associated with EMB resistance. The STR resistance was mediated with two genes, rpsL and gidB. The nucleotide substitutions are indicated within the bracket where the capitalized letter is the substituted nucleotide.