Table 1.
Metabolites with significant (p < 0.05) change in partition ratio. Ratios expressed as average of all mice within genotype (i.e. KOHippo/KOCortex) (n = 5)
| Feature# | M/z | RT | p value | FC | Log2(FC) | KOHippo/KOCortex | WTHippo/WTCortex | ID |
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| 2245 | 1541.0223 | 28.39342 | 0.000907 | 6.8923 | 2.785 | 1.48200753 | 0.215023588 | CL(78:13) |
| 2339 | 1545.0439 | 30.19693 | 0.006922 | 4.262 | 2.0915 | 1.463586611 | 0.343399848 | CL(78:11) |
| 1540 | 619.52859 | 21.45607 | 0.009393 | 0.437 | − 1.1943 | 0.830521446 | 1.900523832 | DG(36:3) |
| 3076 | 914.54252 | 24.67435 | 0.01232 | 3.036 | 1.6022 | 1.691953198 | 0.557299834 | |
| 3266 | 1224.8029 | 28.47826 | 0.015475 | 2.9849 | 1.5777 | 2.661825002 | 0.891769288 | |
| 1161 | 1224.8033 | 27.96628 | 0.015729 | 2.5682 | 1.3608 | 2.39593153 | 0.932918216 | |
| 3750 | 760.58833 | 23.15106 | 0.017241 | 4.4833 | 2.1646 | 2.374186746 | 0.52956004 | PC(34:1) |
| 3717 | 760.63915 | 13.83236 | 0.019338 | 4.7603 | 2.2511 | 2.016014007 | 0.423501454 | TG(44:4) |
| 3362 | 683.5033 | 20.55179 | 0.020438 | 0.24804 | − 2.0114 | 0.480660008 | 1.937868963 | PA(P-36:3) |
| 2924 | 1525.1976 | 15.98834 | 0.020848 | 2.4234 | 1.277 | 2.210609887 | 0.912186112 | |
| 2082 | 379.28289 | 24.94067 | 0.021525 | 5.0457 | 2.3351 | 1.036299124 | 0.205382444 | MG(20:4) |
| 2660 | 844.67999 | 36.38692 | 0.024484 | 6.4056 | 2.6793 | 5.12294113 | 0.799755633 | PE-Nme(42:1) |
| 2579 | 738.03114 | 17.5781 | 0.025059 | 3.1307 | 1.6465 | 3.367349222 | 1.075576499 | |
| 1108 | 1208.3911 | 24.68311 | 0.026134 | 2.6287 | 1.3943 | 2.288052422 | 0.870420822 | |
| 2972 | 1196.7696 | 34.11828 | 0.026748 | 5.7922 | 2.5341 | 2.749256348 | 0.474646828 | Ganglioside GM3 (36:2) |
| 3661 | 841.53216 | 30.91421 | 0.027573 | 0.047042 | − 4.4099 | 0.00990206 | 0.126812919 | PI(P-36:5) |
| 3472 | 914.54248 | 24.59988 | 0.027738 | 3.6168 | 1.8547 | 1.832314343 | 0.506609079 | |
| 1470 | 1524.1937 | 15.97183 | 0.027769 | 3.1886 | 1.6729 | 3.744400781 | 1.174307862 | |
| 3510 | 1233.8481 | 31.37504 | 0.028188 | 0.10502 | − 3.2513 | 0.022294484 | 0.127725196 | |
| 2665 | 760.64102 | 14.68543 | 0.029931 | 0.29305 | − 1.7708 | 1.45868118 | 4.977511093 | TG(44:4) |
| 3517 | 1497.0355 | 35.23429 | 0.031846 | 2.9383 | 1.555 | 1.353905614 | 0.460785799 | |
| 4030 | 838.63259 | 14.46687 | 0.039145 | 0.23455 | − 2.092 | 0.984924332 | 4.19924118 | PE-Nme(42:4) |
| 1682 | 756.55241 | 15.49642 | 0.039495 | 3.0165 | 1.5929 | 1.894507631 | 0.62804463 | PC(34:3) |
| 1164 | 1520.1638 | 33.82245 | 0.040437 | 2.2832 | 1.1911 | 1.017646038 | 0.445704607 | |
| 4280 | 1148.7733 | 34.60997 | 0.040507 | 4.3776 | 2.1301 | 4.343095949 | 0.992120507 | |
| 3708 | 866.66418 | 17.30173 | 0.041693 | 3.9187 | 1.9704 | 2.445672862 | 0.6240973 | PE-Nme(44:4) |
| 4277 | 936.73614 | 25.33598 | 0.043101 | 0.44316 | − 1.1741 | 1.070164227 | 2.414839826 | |
| 1671 | 816.63931 | 16.1634 | 0.046744 | 3.1983 | 1.6773 | 2.329997034 | 0.728515739 | PC(38:1) |
| 2670 | 869.65258 | 21.9099 | 0.049855 | 2.2549 | 1.173 | 2.156816436 | 0.956515904 | |
*
Provided annotation represent simple m/z based fit and can be affected by in source fragmentation. Therefore, it is important to note that all identifications are tentative, and their validation would require additional characterization involving purified standards and extensive MSn analysis