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. 2023 Sep 25;13(15):5170–5182. doi: 10.7150/thno.87248

Figure 5.

Figure 5

A: T2w MR images OVA-Gl261 bearing mice following intratumoral iron oxide NP labeled OT-1 ACT. Representative examples of progressive disease (PD), stable disease (SD), partial response (PR) and complete response (CR) are shown. B: Response towards ACT with OT-1 T cells. n = 27 mice. Pooled data from two independent biological experiments C: T2* relaxation times of the tumor within the response groups. PBS was injected in a negative control group. D: T2w MRI of intratumorally injected, NP labeled OT-1 T cells in Gl261-Ova model on day 14 after ACT in correlation to iDISCO cleared LSM images of CD3+ T cells. Arrowheads indicate sites of T cells accumulations. Scale bar is 500 µm.