Figure 5.

GSH-activatable nanomedicine for cancer theranostics. A) GSH-activatable iodine-conjugated Pt(IV) nanomedicine (Bio-Pt-I) for computed tomography-guided chemotherapy. a) Schematic of Bio-Pt-I design. b) Western blots of Bcl-2 expressed in tumors after various treatments. c) 3D volume-rendering CT images of PDX tumor models injected with Bio-Pt-I. Reproduced with permission ¹⁴⁶. Copyright 2022, American Chemical Society. B) A GSH-activatable nanoprobe for photoacoustic imaging and photothermal therapy. a) Schematic design of the nanoprobe. b) PAI images of tumor sites treated with the nanoprobe (i), Au@PDA-PEGm NPs (ii), and PBS (iii) at different time points. Reproduced with permission ¹⁴⁸. Copyright 2022, American Chemical Society.