Figure 8.

Light-activatable nanomedicine for cancer theranostics. A) A light-activatable amphiphilic dendrimer, LIA, as a fluorescence imaging-assisted immunological adjuvant. a) Schematic of the procedure for preparing LIA and triggering its adjuvant function. b) Fluorescence images of 4T1 tumor models treated with free Ce6 and LIA. c) H&E staining of lung tissues after different treatments, and black circles represented metastatic nodules, scale bar: 500 μm. Reproduced with permission ¹⁶⁸. Copyright 2021 the Authors, published by Springer Nature. B) A light-responsive liquid metal (LM)-based immunostimulator for NIR-light triggered PTT and release of immunomodulators (anti-PD-L1 and imiquimod (IMIQ)). a) Scheme for preparation and structure of anti-PD-L1-PEG-IMIQ-ICG-LM. b) Fluorescence images of CT26-bearing mice and their resected organs after injection of this theranostic nanomedicine. c) Survival rates of the murine tumor model after different treatments. Reproduced with permission ¹⁶⁹. Copyright 2023, published by Wiley-VCH.