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[Preprint]. 2023 Oct 16:2023.10.11.561918. [Version 1] doi: 10.1101/2023.10.11.561918

Figure 3. TNF, IL1α, and C1q knockout reduces CD68+ cells in the peri-infarct area 7- and 30-days post ischemic stroke.

Figure 3.

(A) Representative images of the CD68+ cells in the peri-infarct area for wildtype (WT) and Tnf−/−Il1a−/−C1qa−/− triple knockout (TKO) mice 1-, 7-, and 30-days post ischemia. (B) No difference was found in CD68+ cells in the peri-infarct area 1 day after ischemia between the WT and TKO mice, t (29) = 0.29, p = .285. (C) TKO mice had significantly reduced CD68+ cells in the peri-infarct area than WT mice 7 days post-stroke, t (15) = 3.51, p = .002. (D) TKO mice had significantly reduced CD68+ cells in the peri-infarct area than WT mice 30 days post-stroke, t (19) = 4.55, p = .0001. * p < .05, ** p < .001, *** p < .0001. Abbreviations: CD68; Cluster of Differentiation 68, TKO, Tnf−/−Il1a−/−C1qa−/− triple knockout mouse; WT, wild type.