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[Preprint]. 2023 Oct 16:2023.10.11.561918. [Version 1] doi: 10.1101/2023.10.11.561918

Figure 5. TNF, IL1α, and C1q deletion reduces behavioral deficits after ischemic stroke.

Figure 5.

(A) Tnf−/−Il1a−/−C1qa−/− triple knockout (TKO) mice a significantly further distance on the rotating beam as the wildtype (WT) mice, F (1, 24) = 0.3969, p = .026. A post-hoc analysis revealed that TKO mice made fewer errors 1- (p = .0358) and 3 days (p = .0244) after stroke. (B) TKO mice mad significantly fewer errors on the tapered beam task than WT mice, F (1, 24) = 6.342, p = .0189. A post-hoc analysis revealed that TKO mice made fewer errors 1- (p < .0124), 3- (p < .023), 7- (p < .0329), and 14 (p < .0453) days after stroke. (C) TKO mice and WT mice made a similar number of contralateral forelimb errors on the grid walk task, F (1, 32.008) = 0.015, p = .91. * p < .05. Abbreviations: TKO, Tnf−/−Il1a−/−C1qa−/− triple knockout mouse; WT, wild type.