Figure 6: Immune-dampened profile of t-cells in huNOG-EXL tumors.
A, Gating strategy for determining the activation state of t-cells and regulatory-like t-cells. B, Representative data showing the activation state of the CD3+ cells harvested from tumors under different treatment categories through the presence of the surface markers: CD25, CD44, CD69 and PD-1 and regulatory-like cells (CD3+CD25+PD-1+). C, Quantitation showing the expression of CD25, D, CD44, E, CD69, F, PD-1, G, regulatory-like t-cells.