Fig. 5 |. Propionate and vitamin B₁₂ supplementation increase rifampicin and bedaquiline resistance of Mtb in a PDIM-dependent manner.

a, Sensitivity of PDIM(+) and PDIM(−) Mtb H37Rv to rifampicin (RIF), b, bedaquiline (BDQ), and c, isoniazid (INH), in standard 7H9/OADC/glycerol/tyloxapol media and supplemented with either 0.1 mM propionate or 7.4 μM vitamin B₁₂ (10 μg/ml). *P < 0.001 for both propionate and vitamin B₁₂ versus unsupplemented; two-way ANOVA with Tukey’s multiple comparison test. Mean ± SD for n = 4 biological replicates from two independent experiments.