Table 4.
CSF Volume Related Mediated Effects
| Outcome | Mediator | Effect | Total Effect | Direct Effect | Mediated Effect | |||
|---|---|---|---|---|---|---|---|---|
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| Effect (CI: Lower, Upper) | p | Effect (CI: Lower, Upper) | p | Effect (CI: Lower, Upper) | p | |||
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| NIHTB-CB: Flanker Attention & Inhibitory Control | Fourth Ventricle | Weight at MRI (grams) | −0.006762 (−0.418534, 0.449423) | 0.958 | −0.000052 (−0.000181, 0.000081) | 0.438 | −0.006710 (−0.418546, 0.449454) | 0.958 |
| COI Score | −0.030023 (−0.478977, 0.336943) | 0.858 | −0.020142 (−0.105127, 0.066016) | 0.638 | −0.009881 (−0.489749, 0.329225) | 0.986 | ||
| Height at MRI (centimeters) | 0.023614 (−0.422393, 0.493008) | 0.920 | 0.019688 (−0.112312, 0.166341) | 0.824 | 0.003926 (−0.436846, 0.430247) | 0.988 | ||
| Weight at birth (grams) | −0.002269 (−0.417920, 0.385511) | 0.960 | 0.000937 (−0.003447, 0.005263) | 0.648 | −0.003206 (−0.418606, 0.384749) | 0.980 | ||
| Post-conceptual age at birth (weeks) | 0.843149 (−0.221515, 1.970000) | 0.138 | 0.744778 (−0.394730, 1.859795) | 0.202 | 0.098371 (−0.437291, 0.769684) | 0.692 | ||
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| D-KEFS VFT: Condition 3 - Category Switching | Left Inferior Lateral Ventricle | CHD cohort | −0.380864 (−1.686661, 0.905008) | 0.566 | −0.245388 (−1.434924, 0.946768) | 0.682 | −0.135476 (−0.603171, 0.298993) | 0.514 |
| MDQ Animal Income Estimate Coded | −0.043386 (−0.459799, 0.364858) | 0.796 | 0.017543 (−0.264681, 0.307318) | 0.900 | −0.060929 (−0.380182, 0.207160) | 0.678 | ||
| Handedness | 0.208907 (−1.551477, 1.717087) | 0.780 | 1.145508 (−0.517746, 2.709293) | 0.174 | −0.936601 (−1.865280, -0.238018) | 0.002 | ||
| Number of days on ECMO after heart transplant 1 | 1.792254e-03 (−2.680751e-01, 2.751909e-01) | 0.996 | −1.120856e-12 (−1.200817e-12, -1.040902e-12) | 0.000 | 1.792254e-03 (−2.680751e-01, 2.751909e-01) | 0.996 | ||
| Subject history of cardiac catheterization prior to cardiac surgery | −0.685753 (−2.824055, 1.405739) | 0.482 | −0.447707 (−2.476516, 1.586017) | 0.642 | −0.238046 (−1.032594, 0.367492) | 0.434 | ||
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| Left Lateral Ventricle | CHD cohort | −0.410424 (−1.660102, 0.852292) | 0.508 | −0.364059 (−1.524374, 0.851598) | 0.548 | −0.046365 (−0.515092, 0.358640) | 0.810 | |
| MDQ Annual Income Estimate Coded | −0.038957 (−0.410290, 0.357207) | 0.844 | 0.003631 (−0.293199, 0.273283) | 0.944 | −0.042588 (−0.309910, 0.223769) | 0.752 | ||
| Handedness | 0.259337 (−1.367200, 1.919285) | 0.752 | 0.579670 (−0.990846, 2.177115) | 0.452 | −0.320333 (−0.985265, 0.122688) | 0.196 | ||
| Number of days on ECMO after heart transplant 1 | −1.109568e-03 (−2.446899e-01, 2.307349e-01) | 0.984 | −1.792123e-11 (−1.929688e-11, −1.659108e-11) | 0.000 | −1.109568e-03 (−2.446899e-01, 2.307349e-01) | 0.984 | ||
| Subject history of cardiac catheterization prior to cardiac surgery | −0.635222 (−2.689408, 1.366682) | 0.568 | −0.573532 (−2.574332, 1.337282) | 0.590 | −0.061690 (−0.662977, 0.539678) | 0.794 | ||
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| Right Inferior Lateral Ventricle | CHD cohort | −0.396915 (−1.632055, 0.889799) | 0.558 | −0.366277 (−1.519817, 0.829736) | 0.554 | −0.030638 (−0.511852, 0.443293) | 0.932 | |
| MDQ Annual Income Estimate Coded | −0.043394 (−0.467803, 0.361677) | 0.790 | −0.028241 (−0.324283, 0.241377) | 0.828 | −0.015154 (−0.324303, 0.275567) | 0.940 | ||
| Handedness | 0.219621 (−1.414867, 1.839462) | 0.756 | 0.644776 (−0.921614, 2.218761) | 0.430 | −0.425155 (−1.158730, 0.092854) | 0.130 | ||
| Number of days on ECMO after heart transplant 1 | −0.002617 (−0.267076, 0.281632) | 0.964 | 0.000000 (0.000000, 0.000000) | 0.000 | −0.002617 (−0.267076, 0.281632) | 0.964 | ||
| Subject history of cardiac catheterization prior to cardiac surgery | −0.572272 (−2.634059, 1.582015) | 0.576 | −0.708496 (−2.686858, 1.325344) | 0.472 | 0.136224 (−0.543187, 0.875045) | 0.694 | ||
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| Right Lateral Ventricle | CHD cohort | −0.466470 (−1.806301, 0.775060) | 0.480 | −0.360675 (−1.577958, 0.832312) | 0.574 | −0.105795 (−0.547331, 0.263437) | 0.580 | |
| MDQ Annual Income Esimate Coded | −0.042692 (−0.417691, 0.325716) | 0.810 | 0.014676 (−0.307258, 0.309078) | 0.928 | −0.057368 (−0.314283, 0.139172) | 0.624 | ||
| Handedness | 0.228540 (−1.427109, 2.064842) | 0.764 | 0.488837 (−1.100543, 2.183295) | 0.564 | −0.260297 (−0.837532, 0.155706) | 0.258 | ||
| Number of days on ECMO after heart transplant 1 | 3.337912e-03 (−2.140636e-01, 2.231633e-01) | 0.958 | −1.530327e-11 (−1.635328e-11, −1.431193e-11) | 0.000 | 3.337912e-03 (−2.140636e-01, 2.231633e-01) | 0.958 | ||
| Subject history of cardiac catheterization prior to cardiac surgery | −0.576423 (−2.664443, 1.389169) | 0.586 | −0.683708 (−2.708143, 1.191630) | 0.476 | 0.107285 (−0.441634, 0.722985) | 0.698 | ||
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| Cortex - Right Hemisphere: Orbital part of the inferior frontal gyrus | CHD cohort | −0.442431 (−1.661565, 0.897919) | 0.532 | −0.355730 (−1.456383, 0.910247) | 0.582 | −0.086701 (−0.611034, 0.431646) | 0.710 | |
| MDQ Annual Income Estimate Coded | −0.037726 (−0.431376, 0.350581) | 0.848 | −0.078778 (−0.376198, 0.203735) | 0.604 | 0.041052 (−0.255739, 0.354579) | 0.774 | ||
| Handedness | 0.231271 (−1.423201, 1.803395) | 0.756 | 0.062920 (−1.470388, 1.554793) | 0.958 | 0.168352 (−0.412165, 0.888961) | 0.594 | ||
| Number of days on ECMO after heart transplant 1 | −0.000472 (−0.313503, 0.301497) | 0.998 | 0.000000 (0.000000, 0.000000) | 0.000 | −0.000472 (−0.313503, 0.301497) | 0.998 | ||
| Subject history of cardiac catheterization prior to cardiac surgery | −0.553838 (−2.662799, 1.621304) | 0.598 | −0.723282 (−2.647332, 1.359748) | 0.484 | 0.169445 (−0.527931, 1.042433) | 0.690 | ||
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| D-KEFS VFT: Condition 3 - Correct Responses | Right Inferior Lateral Ventricle | COI Score | 0.003663 (−0.272976, 0.277436) | 0.978 | 0.008328 (−0.012765, 0.029849) | 0.458 | −0.004665 (−0.277561, 0.264790) | 0.962 |
| Weight at MRI (grams) | 0.008219 (−0.251538, 0.272001) | 0.950 | −0.000038 (−0.000074, −0.000001) | 0.046 | 0.008257 (−0.251476, 0.272021) | 0.950 | ||
| Weight at birth (grams) | −0.007794 (−0.298534, 0.252996) | 0.934 | −0.000540 (−0.001570, 0.000436) | 0.260 | −0.007254 (−0.297500, 0.254209) | 0.936 | ||
| Height at MRI (centimeters) | −0.024647 (−0.289389, 0.237619) | 0.844 | −0.028228 (−0.065994, 0.010049) | 0.160 | 0.003581 (−0.262112, 0.257291) | 0.932 | ||
| Post-conceptual age at birth (weeks) | −0.077440 (−0.502781, 0.336402) | 0.724 | −0.338536 (−0.654487, −0.052370) | 0.014 | 0.261096 (−0.038263, 0.688108) | 0.084 | ||
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| Cortex - Right Hemisphere: Planum polare of the superior temporal gyrus | COI Score | 0.006708 (−0.285164, 0.298221) | 0.974 | 0.001285 (−0.019159, 0.022120) | 0.906 | 0.005422 (−0.289853, 0.301534) | 0.978 | |
| Weight at MRI (grams) | −0.000288 (−0.315904, 0.306895) | 0.976 | −0.000035 (−0.000070, 0.000002) | 0.064 | −0.000253 (−0.315874, 0.306931) | 0.976 | ||
| Weight at birth (grams) | −0.001227 (−0.318159, 0.299589) | 0.978 | −0.000295 (−0.001271, 0.000591) | 0.542 | −0.000932 (−0.317792, 0.299910) | 0.980 | ||
| Height at MRI (centimeters) | −0.023735 (−0.344694, 0.286938) | 0.884 | −0.025757 (−0.064319, 0.012504) | 0.196 | 0.002021 (−0.316746, 0.304458) | 0.962 | ||
| Post-conceptual age at birth (weeks) | −0.072838 (−0.509102, 0.353151) | 0.744 | −0.126614 (−0.378980, 0.133416) | 0.346 | 0.053776 (−0.287534, 0.412512) | 0.762 | ||
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| Cortex - Left Hemisphere: Straight gyrus, Gyrus rectus | COI Score | 0.011627 (−0.347452, 0.405283) | 0.932 | 0.002138 (−0.017261, 0.023035) | 0.854 | 0.009489 (−0.353438, 0.407452) | 0.944 | |
| Weight at MRI (grams) | −0.007190 (−0.366547, 0.358690) | 0.962 | −0.000030 (−0.000065, 0.000004) | 0.094 | −0.007160 (−0.366507, 0.358777) | 0.962 | ||
| Weight at birth (grams) | −0.005068 (−0.382023, 0.382465) | 0.962 | 0.000009 (−0.000786, 0.000893) | 0.986 | −0.005077 (−0.381759, 0.382685) | 0.964 | ||
| Height at MRI (centimeters) | −0.014493 (−0.364933, 0.364977) | 0.926 | −0.009196 (−0.048422, 0.027443) | 0.616 | −0.005297 (−0.358873, 0.372211) | 0.958 | ||
| Post-conceptual age at birth (weeks) | −0.066222 (−0.539522, 0.397853) | 0.752 | −0.052860 (−0.293346, 0.189971) | 0.704 | −0.013361 (−0.434285, 0.394404) | 0.922 | ||
Notes. Abbreviations: COI Score=Childhood Opportunity Index nationally-normed overall score based on zip code/COI year. ECMO=extracorporeal membrane oxygenation. MDQ=Maternal Demographic Questionnaire. NIHTB-CB=NIH Toolbox Cognitive Battery. VFT=Verbal Fluency Test. Handedness: pulled from NIHTB Grip Strength and Grooved Pegboard Dexterity Test. MDQ Annual Income Estimate Coded: 0=choose not to answer; 1=<$25,000; 2=$25,000-$34,999; 3=$35,000-$49,999; 4=$50,000-$74,999; 5=$75,000-$99,999; 6=$100,000-$149,999; 7=$150,000≤.