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A schematic diagram depicting the likely mechanisms that trigger Nrf2 activation and translocation into the nucleus. DLDH inhibition by MICA and DLDH sulfenation could cause a stress condition inducing Nrf2 activation that plays a protective role in ischemic stroke injury. MICA, 5-methoxyindole-2-carboxylic acid; Nrf2, nuclear factor-erythroid factor 2-related factor 2.
