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Resistance of in vivo-derived viruses to PZ neutralization in vitro. The resistance to PZ of the parent A2 and in vitro-derived (MS412 and F212) and in vivo-derived (MCRL5, A2R3, and A2R4) viruses was assessed by microneutralization (36). PZ concentrations are show in micrograms per milliliter on the x axis, and mean absorbance (optical density) is shown on the y axis.
