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Effect of the H/N-Ras inhibitor FTI-277 on transformation of fibroblastsa
| Inhibitor or DNA | No. of foci in:
|
||||
|---|---|---|---|---|---|
| Expt 1 | Expt 2 | ||||
| FTI-277 (μM) | 0 | 5 | 0 | 0.5 | 1 |
| Transfected DNA | |||||
| None | 0 | 0 | 0 | 0 | 0 |
| pcDNA3.1 | 0 | 0 | 0 | 0 | 0 |
| v-mos | 32 | 20 | 23 | 18 | 18 |
| H-ras | 72 | 0 | 61 | 2 | 0 |
| pCMV3ΔGP | 36 | 0 | 47 | 15 | 16 |
NIH 3T3 fibroblasts were tested in transformation assays in the presence of FTI-277 as described for Table 1. Foci were scored at 15 to 17 days posttransfection.
