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. 2005 Apr;79(7):4357–4368. doi: 10.1128/JVI.79.7.4357-4368.2005

FIG. 8.

FIG. 8.

Infectivities of wild-type and CCR5(ΔNt)-adapted HIV-1 in HeLa-CD4 cells expressing mutant coreceptors. Replication competent preparations of wild-type JR-CSF, CCR5(Δ16)-adapted virus, or CCR5(Δ18)-adapted virus populations were used to infect HeLa-CD4 cells transiently expressing CCR5(G163R), CCR5(Δ18), or CCR5(Δ18,G163R). Relative infectivity values were obtained by dividing titers obtained in each transfected cell line by titers generated in HeLa-CD4 cells transfected with wild-type CCR5. The high relative infectivity values for CCR5(G163R)-transfected cells exhibited by these replication-competent viruses are caused by the high titers of the replication-competent viruses and the high expression level of CCR5(G163R) in this transient assay (34, 51). The averages from two or three independent experiments are shown, and error bars are the ranges or standard errors of the means.