TABLE 2.
Cox regression model for death
| Univariable analysis | Multivariable analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| 95% CI | 95% CI | |||||||
| HR | Lower | Upper | P | HR | Lower | Upper | P | |
| Age | 0.979 | 0.942 | 1.019 | 0.300 | — | — | — | — |
| Presence of viral hepatitis | 0.956 | 0.432 | 2.119 | 0.913 | — | — | — | — |
| Presence of cirrhosis | 1.100 | 0.455 | 2.656 | 0.833 | — | — | — | — |
| AFP ≥ 400 | 3.103 | 1.318 | 7.306 | 0.010 | 3.882 | 1.558 | 9.674 | 0.004 |
| ALBI score, per point | 3.859 | 1.953 | 7.626 | <0.001 | 4.841 | 2.242 | 10.452 | <0.001 |
| Second vs. later systemic line | 1.417 | 0.633 | 3.171 | 0.397 | — | — | — | — |
| BCLC A/B vs. C | 0.653 | 0.277 | 1.543 | 0.332 | — | — | — | — |
| Previous IO exposure | 1.068 | 0.477 | 2.389 | 0.874 | — | — | — | — |
Abbreviations: ALBI, albumin-bilirubin; BCLC, Barcelona Clinic for Liver Cancer classification; IO, immune-oncological therapy.