TABLE 6.
Pathogenicity of Vietnam H5 viruses in BALB/c mice
| Virus | MID50 (log10EID50) | LD50 (log10 EID50) | Maximum % weight loss (day) | Mean virus titer ± SEb (log10 EID50/ml)a
|
|||||
|---|---|---|---|---|---|---|---|---|---|
| Day 3
|
Day 6
|
||||||||
| Lung | Brain | Spleen | Lung | Brain | Thymus | ||||
| HK/483/97 (H5N1) | 0.5 | 1.8 | 25 (4) | 7.1 ± 1.0 | 1.6 ± 0.5 | 3.5 ± 0.2 | 5.9 ± 0.3 | 3.7 ± 0.4 | 2.9 ± 0.1 |
| Gs/VN/113/01 (H5N1) | 4.3 | 6.5 | 3.7 (9) | 3.9 ± 1.2 | ≤0.8 | ≤0.8 | 5.2 ± 0.5 | ≤0.8 | 3.9 ± 0.6 |
| Dk/VN/342/01 (H5N2) | 4.8 | >7.0 | 3.5 (7) | 4.8 ± 1.2 | ≤0.8 | ≤0.8 | 7.1 ± 1.0 | ≤0.8 | ≤0.8 |
a
Mice were infected with 106 EID50 of the various viruses. On the indicated days, mice were euthanatized and tissues were collected and subsequently homogenized and titered in eggs for the presence of infectious virus. The limit of detection for lung tissues was 101.5 EID50/ml and for other tissues was 100.8 EID50/ml.
b
SE, standard error.