FIG. 7.

Induction of mRNAs for OAS1a (A) and RIG-I (B) after poly(I:C) treatment. PVR-transgenic mice was administered poly(I:C) (solid bars) or mock treated (open bars). RNA was prepared from the mice 1 day after administration. The amounts of RNA were determined by real-time quantitative PCR. (C) Survival of infected mice. PVR-transgenic mice administered poly(I:C) (solid circles) or mock treated (open circles) (13 mice each) were challenged intracerebrally with 10⁴ PFU of poliovirus. Mice were observed for 3 weeks. The survival rate of poly(I:C)-treated mice was significantly higher than that of mock-treated mice (P < 0.05, log-rank test).