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. Author manuscript; available in PMC: 2023 Oct 31.
Published in final edited form as: Matrix Biol. 2016 Nov 15;62:40–57. doi: 10.1016/j.matbio.2016.11.003

Figure 2.

Figure 2.

Porcine aortic valves demonstrate altered expression of HA homeostatic markers with age. Expression patterns of HAS2 (A1–4), HYAL1 (B1–4), KIAA1199 (C1–4), CD44 (D1–4), RHAMM (E1–4), TSG6 (F1–4) and pERK1/2 (G1–4) in valves classified as young (1–3 month old), adult (6–9 month old) or aged (>2 year old) are shown. Arrows and arrowheads denote cell and ECM expression respectively. Parentheses mark the regions of expression. †: vs young p<0.05; ‡: vs adult p<0.05. f, fibrosa; s, spongiosa; v, ventricularis. The orientation provided by the use of f, s, v in panels A-D apply to all the microscopic image panels in this figure. Scale bar: 200 μm.