Skip to main content
. 2005 Apr;79(7):3920–3929. doi: 10.1128/JVI.79.7.3920-3929.2005

TABLE 1.

Mutant cell lines used

Cell line Lineage Relevant altered protein Affected pathway(s)
HEK293 None TLR3 nonresponsive
293/TLR3 HEK293 TLR3 TLR3 responsive
2fTGH HT1080 None None
2F-SR 2fTGH IκB NF-κB signaling
1080.10 HT1080 Increased IRF-3 IRF-3 signaling
U4C 2fTGH Jak1 IFN signaling
U4C.2 U4C Increased IRF-3 IRF-3 and IFN signaling
P2.1 U4C Decreased IRF-3 IRF-3 and IFN signaling
P2.1.6 P2.1 Increased IRF-3 IRF-3 and IFN signaling
P2.1.17 P2.1 Increased IRF-3 IRF-3 and IFN signaling
HHS Vulnerability Disclosure