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Mutant cell lines used
| Cell line | Lineage | Relevant altered protein | Affected pathway(s) |
|---|---|---|---|
| HEK293 | None | TLR3 nonresponsive | |
| 293/TLR3 | HEK293 | TLR3 | TLR3 responsive |
| 2fTGH | HT1080 | None | None |
| 2F-SR | 2fTGH | IκB | NF-κB signaling |
| 1080.10 | HT1080 | Increased IRF-3 | IRF-3 signaling |
| U4C | 2fTGH | Jak1 | IFN signaling |
| U4C.2 | U4C | Increased IRF-3 | IRF-3 and IFN signaling |
| P2.1 | U4C | Decreased IRF-3 | IRF-3 and IFN signaling |
| P2.1.6 | P2.1 | Increased IRF-3 | IRF-3 and IFN signaling |
| P2.1.17 | P2.1 | Increased IRF-3 | IRF-3 and IFN signaling |
