TABLE 1.
Mutant cell lines used
Cell line | Lineage | Relevant altered protein | Affected pathway(s) |
---|---|---|---|
HEK293 | None | TLR3 nonresponsive | |
293/TLR3 | HEK293 | TLR3 | TLR3 responsive |
2fTGH | HT1080 | None | None |
2F-SR | 2fTGH | IκB | NF-κB signaling |
1080.10 | HT1080 | Increased IRF-3 | IRF-3 signaling |
U4C | 2fTGH | Jak1 | IFN signaling |
U4C.2 | U4C | Increased IRF-3 | IRF-3 and IFN signaling |
P2.1 | U4C | Decreased IRF-3 | IRF-3 and IFN signaling |
P2.1.6 | P2.1 | Increased IRF-3 | IRF-3 and IFN signaling |
P2.1.17 | P2.1 | Increased IRF-3 | IRF-3 and IFN signaling |