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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: J Pain. 2023 Jun 12;24(11):1980–1993. doi: 10.1016/j.jpain.2023.06.006

Figure 5: C781 transiently reverses mechanical hypersensitivity in response to paclitaxel treatment.

Figure 5:

Baseline (BL) paw withdrawal thresholds and facial grimace scores for male and female ICR mice were obtained before paclitaxel treatment (4 mg/kg IP every other day for 4 days). Before C781 treatment (red arrow), establishment of CIPN was checked to ensure that animals were mechanically hypersensitive and grimacing. C781 was injected at 10 mg/kg into the intraperitoneal space. (A) Mice treated with C781 transiently showed higher mechanical thresholds. (B) C781 treatment had no effect on facial grimacing. For the Veh group, n = 3 females and n = 4 males. For the C781 group, n = 4 females and n = 3 males. **p<0.01. For both paw withdrawal threshold and grimace scores, repeated measures two-way ANOVA with Sidak’s multiple comparisons test was used.