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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Neurourol Urodyn. 2023 Aug 17;42(8):1839–1848. doi: 10.1002/nau.25267

FIGURE 2.

FIGURE 2

Dynamic network analysis depicts correlations between inflammatory mediators that evolve with time. (A–C) Network connectivity remains relatively low. IL-1β is correlated with both IL-4 and TNF-α between 210 and 270 min. (D–F) Network complexity increases and then resolves by 510 min. GM-CSF is a key node of inflammation during peak network complexity. (G–I) Network complexity peaks between 570 and 630 min, during which IL-18 and IL-1β have the greatest number of connections with inflammatory mediators. By the end of the experiments, IL-5, IL-6, and MCP-1 are all connected with each other between 630 and 690 min.