FIGURE 3.

Dynamic network analysis network complexity. Network complexity at any dynamic time interval is calculated as follows: $\frac{numberofnodes\times numberofedges}{maximumpossibleedgesbetweenallnodes}$. DyNA indicates two peaks in network complexity at 390–450 min and 570–630 min respectively. Between the two peaks in network complexity, which indicates a rise in coordinated inflammatory responses, is a trough at which network complexity is 0. The fluctuations in the rise and fall of network complexity is indicative of the temporally sensitive evolution of the inflammatory response characteristic of IC/BPS. CYP, cyclophosphamide; DyNA, dynamic network analysis; IC/BPS, interstitial cystitis and bladder pain syndrome.