TABLE 2.

Associations of premenopausal bilateral oophorectomy (PBO), with or without concurrent or preceding hysterectomy, with odds of chronic conditions overall and by age at PBO

	All PBO vs. referents		Early PBO (<46 years) vs. referents		Late PBO (46–49 years) vs. referents
Chronic condition	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Arthritis	1.74 (1.19–2.53)	0.004	1.64 (1.06–2.55)	0.026	1.92 (1.16–3.18)	0.011
Asthma	1.37 (0.87–2.18)	0.176	1.74 (1.03–2.93)	0.037	0.94 (0.50–1.76)	0.848
Bone fracture	2.17 (0.97–4.83)	0.059	2.86 (1.17–6.98)	0.021	1.52 (0.54–4.25)	0.426
Cancer	1.19 (0.81–1.74)	0.371	1.21 (0.77–1.91)	0.402	1.25 (0.76–2.03)	0.378
COPD	2.69 (1.03–7.05)	0.044	2.86 (0.96–8.59)	0.060	2.25 (0.58–6.97)	0.161
Diabetes	1.32 (0.79–2.20)	0.287	1.31 (0.72–2.38)	0.378	1.31 (0.69–2.49)	0.412
Hypertension	1.11 (0.78–1.58)	0.577	1.08 (0.71–1.64)	0.725	1.12 (0.70–1.78)	0.634
Hyperlipidemia	1.18 (0.83–1.69)	0.359	1.32 (0.86–2.02)	0.200	0.96 (0.61–1.53)	0.878
Irregular heart rhythm	1.542 (0.89–2.27)	0.146	1.68 (0.97–2.91)	0.064	1.18 (0.64–2.15)	0.594
Kidney disease	1.47 (0.56–3.89)	0.435	1.48 (0.44–5.00)	0.526	1.64 (0.53–5.09)	0.388
Liver disease	0.71 (0.23–2.17)	0.546	0.51 (0.13–2.08)	0.347	0.89 (0.22–3.55)	0.868
MCI/dementia	0.90 (0.56–1.45)	0.665	0.79 (0.77–1.91)	0.406	1.06 (0.58–1.94)	0.850
Obstructive sleep apnea	2.06 (1.36–3.11)	<0.001	2.00 (1.23–3.26)	0.005	2.21 (1.33–3.66)	0.002
Osteoporosis	1.00 (0.63–1.57)	0.997	1.06 (0.62–1.82)	0.836	0.92 (0.51–1.64)	0.768
Thyroid disease	0.96 (0.65–1.41)	0.834	1.02 (0.65–1.60)	0.942	0.88 (0.53–1.45)	0.607
TIA	0.78 (0.34–1.78)	0.553	0.64 (0.22–1.88)	0.417	0.87 (0.32–2.39)	0.787

All models adjusted for age.

CI, confidence interval; COPD, chronic obstructive pulmonary disease; MCI, mild cognitive impairment; OR, odds ratio; PBO, premenopausal bilateral oophorectomy; TIA, transient ischemic attack.