Table 5:
Exposure to different sedatives and analgesics before, during and after NEC Onset
| Variable | N | Overall | Mild/no WMI | Moderate/Severe WMI | P-Value |
|---|---|---|---|---|---|
| N=67 | N=48 | N=19 | |||
| From Birth Until NEC onset | |||||
| Morphine mg/kg, mean (± SD) | 61 | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.99 |
| Fentanyl mg/kg, mean (± SD) | 67 | 0.0 (0.1) | 0.0 (0.1) | 0.0 (0.0) | 0.029 |
| Midazolam, mg/kg, mean (± SD) | 67 | 0.0 (0.1) | 0.0 (0.1) | 0.0 (0.0) | 0.99 |
| Methadone, mg/kg, mean (± SD) | 67 | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.99 |
| From NEC onset +2 weeks | |||||
| Morphine mg/kg, mean (± SD) | 67 | 0.0 (0.1) | 0.0 (0.1) | 0.0 (0.0) | 0.99 |
| Fentanyl mg/kg, mean (± SD) | 67 | 0.3 (0.3) | 0.3 (0.3) | 0.4 (0.5) | 0.22 |
| Midazolam, mg/kg, mean (± SD) | 67 | 0.2 (1.0) | 0.2 (1.1) | 0.1 (0.2) | 0.99 |
| Methadone, mg/kg, mean (± SD) | 67 | 0.0 (0.0) | 0.0 (0.1) | 0.0 (0.0) | 0.99 |
| From end of 2 weeks to MRI | |||||
| Morphine mg/kg, mean (± SD) | 67 | 2.0 (12.0) | 2.7 (14.1) | 0.2 (0.7) | 0.99 |
| Fentanyl mg/kg, mean (± SD) | 67 | 382 (1051) | 339 (955) | 491 (1286) | 0.46 |
| Midazolam, mg/kg, mean (± SD) | 67 | 2.1 (11.2) | 2.6 (13.2) | 0.8 (2.1) | 0.99 |
| Methadone, mg/kg, mean (± SD) | 67 | 2.0 (10.3) | 2.2 (11.5) | 1.5 (6.6) | 0.99 |