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. 2023 May 18;28(7):3121–3132. doi: 10.1038/s41380-023-02089-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — These genetic risk scores were derived from multi-ancestry and ancestry-specific risk estimates, then applied to an admixed Colombian cohort to evaluate significance and predictive power. The European-based (EUR) PRS was derived from a fixed effect meta-analysis of the summary statistics from Bellenguez et al. and FinnGen used in the meta-GWAS. a, b The maximal AUCs for each genetic risk score with color coding to delineate the source of the risk estimates for scores excluding and then including APOE-e4 variants. P value thresholds that correspond to the maximal AUCs are shown in Table S6.