Table 2.

Biology of Anxiety Biomarkers. Top CFE3 ≥8 (n = 95 probesets, 82 genes).

A.	KEGG Pathways				Ingenuity Pathways
	Term	Count	%	P Value	Top Canonical Pathways	P Value	Overlap
Top candidate biomarkers (n = 95 probesets, 82 genes)	Hippo Signaling Pathway	6	7.4	1.60E-03	CREB Signaling in Neurons	4.56E-06	1.8 % 11/606
	Neuroactive Ligand-receptor Interaction	8	9.9	3.40E-03	Cardiac Hypertrophy Signaling (Enhanced)	1.12E-05	1.8 % 10/542
	Proteoglycans in Cancer	6	7.4	5.20E-03	Relaxin Signaling	1.23E-05	3.9 % 6/155
	Rap1 Signaling Pathway	6	7.4	5.70E-03	Molecular Mechanisms of Cancer	1.57E-05	2.0 % 9/446
	cAMP Signaling Pathway	6	7.4	7.10E-03	G-Protein Coupled Receptor Signaling	1.81E-05	1.6 % 11/702

B.	David					Ingenuity Pathways Disease
Top candidate biomarkers (n = 95 probesets, 82 genes)	#	Term	Count	%	P Value	Diseases and Disorders	P Value	# Molecules
	1	Depression	11	13.6	5.90E-09	Neurological Disease	2.43E-04–7.96E-12	65
	2	Several Psychiatric disorders	14	17.3	6.10E-09	Organismal Injury and Abnormalities	2.46E-04–7.96E-12	77
	3	Alcohol consumption	10	12.3	3.10E-08	Cancer	2.45E-04–2.78E-10	77
	4	Attention deficit disorder Conduct disorder Oppositional defiant disorder	7	8.6	6.60E-07	Hematological Disease	2.24E-04–2.78E-10	45
	5	Tourette Syndrome	5	6.2	2.30E-06	Immunological Disease	1.64E-04–2.78E-10	49
	6	Panic Disorder	6	7.4	5.20E-06
	7	Bulimia	9	11.1	6.20E-06
	8	Schizophrenia	14	17.3	8.40E-06
	9	Tobacco Use Disorder	34	42	1.20E-05
	10	Bipolar Disorder	8	9.9	1.30E-05

C.
Co-morbidity	Percentile Match
Depression	83.33
Alcoholism	72.22
Stress	55.56
Schizophrenia	50.00
Bipolar	44.44
Aging	38.89
Dementia	38.89
PTSD	38.89
Suicide	38.89
Pain	27.78
Phencyclidine	27.78
Cocaine	16.67
Cannabis	11.11
Mood	11.11
ASD	5.56
Fear	5.56
Memory	5.56
Methamphetamine	5.56
Morphine	5.56
Neurological	5.56
Schizoaffective	5.56

A Pathway Analyses, B Diseases, C Psychiatric co-morbidities. C Genomic co-morbidity for Anxiety for Top Biomarkers from Table 1 (n = 19). See also table S3.