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. 2023 Mar 29;28(7):3044–3054. doi: 10.1038/s41380-023-02037-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — After treatments with sham, CURD or CUMR for 3 weeks, the mice behaviours in three groups were tested. a The representative pictures of mice in control, CURD and CUMR groups. b The general appearance parameters (GAP) scores were used to assess the ethogram. c The percentage of sucrose preference was used to test anhedonia. d The total intake volume of water used to test appetite. e The representative pictures of pellets in the sucrose pellets preference test. f The percentage of sucrose pellets preference was operated to assess anhedonia. g The total intake weight of pellets was used to assess appetite. The immobility time in tail suspension (h) and forced swimming tests (i) were recorded in the last 4 of 6 min. j–n In an open field test, the picture of the open field was shown in k. The representative trails of mice treated in control, CURD and CUMR groups were shown in j. The total travelled distance (l), the time spent in central space (m) and the times of vertical counts (n) were recorded in 5 min. Data were presented as mean ± SD, n = 12 per group. One-way ANOVA for comparisons including more than two groups; unpaired two-tailed t-test for two group comparisons. Significant different from control group: **p < 0.01 and ***p < 0.001.