Table 2.
Significant clusters and contrasts from post-hoc ALE meta-analyses.
| Task type, contrast, or interaction | N foci | N BD | N controls | Peak coordinates (MNI) | Location | Cluster size (k voxels) | Peak intensity (Z) |
|---|---|---|---|---|---|---|---|
| Cognitive tasks (BD > C) | 118 | 660 | 781 |
−4, 52, −16 −4, 36, −14 0, 38, 4 −10, 46, −6 |
Medial Orbitofrontal Cortexb Ventral Anterior Cingulate Cortexa,c |
156 220 |
5.56 4.6 4.17 3.42 |
| Cognitive tasks (C > BD) | 250 | 816 | 963 | −32, −2, 52 | Premotor/Supplementary Motor Cortexa,c | 121 | 5.47 |
| Emotional tasks (BD > C) | 451 | 621 | 824 | – | No Convergence | – | – |
| Emotional tasks (C > BD) | 690 | 709 | 896 | 32, 30, −14 | Ventrolateral Prefrontal Cortexa,c | 125 | 5.46 |
| Positive valence | 334 | 623 | 739 | – | No Convergence | – | – |
| Negative valence | 706 | 1127 | 1220 | – | No Convergence | – | – |
| Mixed valence | 436 | 723 | 988 |
−28, −8, −24 −30, −2, −28 −22, −12, −14 |
Amygdala ext. to Hippocampusb | 196 |
3.77 3.66 3.38 |
| Euthymic BD & Resting-state | 230 | 526 | 561 | – | No Convergence | – | – |
| Depressed BD & Resting-state | 372 | 1107 | 1694 |
6, −52, 32 −6, −54, 30 |
Posterior Cingulate Cortexb | 157 |
4.62 3.51 |
| Hypo/manic BD & Resting-state | 28 | 52 | 103 | – | No Convergence | – | – |
|
Euthymic BD & Cognitive tasks |
288 | 738 | 1170 | −20, −70, 52 | Superior Parietal Lobuleb | 121 | 6.21 |
| Depressed BD & Cognitive tasks | 220 | 329 | 481 | – | No Convergence | – | – |
| Hypo/manic BD & Cognitive tasks | 27 | 163 | 198 | −32, −2, 58 | Premotor/Supplementary Motor Cortexa,c | 118 | 5.62 |
| Euthymic BD & Emotional tasks | 663 | 828 | 945 |
10, 10, −6 10, 16, 10 |
Anterior Caudate ext. to Ventral Striatuma | 131 |
4.5 3.65 |
| Depressed BD & Emotional tasks | 546 | 321 | 504 | – | No Convergence | – | – |
| Hypo/manic BD & Emotional tasks | 110 | 123 | 135 | – | No Convergence | – | – |
To avoid double counting, sample sizes (N) correspond to the total number of study participants, not the number of individual experiment participants. No Convergence indicates a null meta-analytic result i.e., no significant clusters were identified.
BD Bipolar Disorder, C Controls, ext. Extended, MNI Montreal Neuroimaging Institute.
aSeen when experiments were pooled.
bSeen both when nested experiments were removed and when experiments were pooled.
cNovel clusters which emerged in the post-hoc meta-analyses and were not observed in the a priori meta-analyses.