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. 2023 May 2;28(7):2716–2727. doi: 10.1038/s41380-023-02076-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Number of loci identified as a function of the sample size (left) or the effective sample size (right) (cases and controls) in the main GWASs published since 2009 (EADI, GERAD, CHARGE, GERAD+, ADGC, IGAP1, IGAP1 + UKB (2017), IGAP1 + UKB (2018), PGC1, IGAP2, IGAP2 + UKB, GR@ACE, PGC2, and EADB [14–27]. The colors indicate the presence or absence of proxy cases in the GWAS. The effective sample size was computed per study included in the meta-analyses, and then summed across studies [124]. The effective sample size for the proxy UKB study was computed by dividing the raw number of proxy cases and proxy controls by four [24, 117].