Fig. 1.

Flow chart for selection of LATE-NC without ADNC and LB cases. Starting from a group of 364 participants from The 90+ Study cohort with completed autopsy and after exclusion of participants without hippocampal or neocortical TDP-43 inclusions, a subgroup of 120 individuals were identified as TDP-43 positive. After further exclusion of dementia-related neuropathologies, including ADNC, limbic or neocortical LB, and ≥1 cortical MVL, the final group consisted of 5 LATE-NC without ADNC and LB cases.