Table 1.
Demographics, clinical findings, and neuropathology in the LATE-NC without ADNC and LB cases
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | |
|---|---|---|---|---|---|
| Age at death, y | 95 | 105 | 100 | 98 | 101 |
| Sex | M | F | F | M | F |
| Education, y | College | College | College | College | College |
| Race | white | white | white | Asian | white |
| Clinical Findings | |||||
| Relevant medical history (Age, y) | TIA (82), stroke (88), syncope (90), COPD (91) | colon cancer (80), staphylococcal meningitis (82), osteoporosis (84), syncope (94), depression (95) | depression (95), syncope (98) | syncope (96), depression (96) | hypothyroidism (57), osteoarthritis (88), anxiety (91), depression (92), syncope (93) |
| Cardiovascular Disease, y | MI (88) | HTN (92), postural hypotension (95), MI (101), AF (105) | HTN (85), VHD (98), AF (98) | MI (90), HTN (91), Mixed HLD (91), CABG (91), chronic hypotension (93), arrythmia (96) | HTN (np), arrhythmia (91), AF (99), CHF (99) |
| Extra-pyramidal signs | Yes | Yes | Yes | Yes | No |
| Postmortem Case Conference Diagnosis | Possible AD | Possible AD | Probable AD | Possible AD | Probable AD |
| Neuropathology | |||||
| Atherosclerosis | No | No | Severe | No | No |
| Arteriolosclerosis | Moderate | Moderate | Moderate | Moderate | Moderate |
| Cerebral amyloid angiopathy | No | No | No | Moderate | No |
| Lewy bodies | No | No | Yes (only OB)* | Yes (only OB)* | No |
| Aging-related tau astrogliopathy | Yes, (MTL)* (HPC)* (SP)* (SUB)* (GM)*(WM)* (PV)* | No | Yes (HPC)* (SP)* | Yes (SMTG)* (WM)* | No |
Every LATE-NC without ADNC and LB case had TDP-43 stage II (hippocampus) and no HS. Medical history abbreviations: TIA, transient ischemic attack; MI, myocardial infarction; HTN, hypertension; VHD, valvular heart disease; AF, atrial fibrillation; HDL, hyperlipidemia; CHF, congestive heart failure; CABG, coronary artery bypass graft surgery. Region abbreviations: OB, olfactory bulb; MTL, medial temporal lobe; HPC, hippocampus; SMTG, superior & middle frontal gyrus. Location abbreviations: WM, white matter; SP, subpial; SUB, subependymal; GM, gray matter; PV, perivascular. Possible AD, clinical evidence to support diagnosis of AD with absence of neuroimaging scans. Probable AD, clinical evidence to support the diagnosis of AD with presence of neuroimaging scans.