Table 3.

Demographics, clinical findings, cognition and neuropathology in LATE-NC without ADNC and LB versus ADNC and PART groups

	LATE-NC	ADNC	PART	PART Braak Stage ≥4
	(n = 5)	(n = 46)	(n = 23)	(n =18)
Age at Death (y)
Mean (SD)	100 (3.64)	98.3 (3.24)	96.1 (2.98)	95.8 (2.97)
[Min, Max]	[95.7, 105]	[92.1, 109]	[91.7, 101]	[91.7, 100.6]
Women, n (%)	3 (60)	34 (73.9)	18 (73.8)	14 (77.8)
College education, n (%)	5 (100)	35 (76.1)	18 (79.3)	16 (88.9)
APOE4 Carrier, n (%)	0 (0)	13 (28.2)	3 (13.0)	0 (0%)
Clinical Findings
Syncope, n (%)	5 (100)***	9 (19.6)***	3 (13)***	2 (11.1)***
Depression, n (%)	4 (80)*	8 (17.4)**	4 (17.4)*	4 (22.2)*
Cardiovascular Disease, n (%)	5 (100)	24 (52.2)	14 (60.9)	14 (77.8)
Osteoarthritis, n (%)	1 (20)	21 (45.6)	17 (74)	14 (77.8)
Extra-pyramidal signs, n (%)	4 (80)**	6 (13)**	1 (4.4)**	1 (5.6)**
Case Conference Diagnosis of AD, n (%)	5 (100)*	20 (44.4)*	8 (36.4)*	3 (16.7)**
Cognitive Measures
Duration of Cognitive Impairment (y), n (%)	6.2	3	2.9	3.2
Dementia diagnosis at last visit before death, n (%)	4 (80)	23 (50.0)	5 (21.7)	1 (5.6)**
Memory domain impairment, n (%)	5 (100)	21 (45.7)	10 (43.5)	9 (50)
Executive function domain impairment, n (%)	4 (80)*	19 (41.3)	6 (26.1)*	6 (33.3)
Visuospatial domain impairment, n (%)	2 (40)	10 (21.7)	2 (8.7)	2 (11.1)
Orientation domain impairment, n (%)	3 (60)	9 (19.6)	5 (8.7)	5 (27.8)
Neuropathology
Atherosclerosis, n (%)	1 (20)	9 (20)	6 (27.3)	4 (22.2)
Arteriolosclerosis, n (%)	5 (100)	27 (60)	14 (63.6)	12 (66.7)

Comparison of social and physical characteristics among those with LATE-NC without ADNC and LB, ADNC, and PART. Syncope, cardiovascular disease, memory domain impairment, and cerebral arteriolosclerosis were found in all LATE-NC without ADNC and LB participants, who also demonstrated a higher prevalence of depression and dementia diagnosis at last visit before death compared to those with ADNC and PART. All participants in the ADNC group have high severity level of ADNC.

^*p < 0.05,

^**p < 0.01,

^***p < 0.001.