TABLE 1.
Results of FACS analysis of BDV cell-to-cell spread assays following treatment with different compounds
| Treatment(concn [μM]) | % of viral disseminationa |
|---|---|
| None | 100 |
| Ara-C (4) | 7.4 ± 1.6 |
| Ara-A (100) | 142.9 ± 10.9 |
| 5-Cl-Ara-C (100) | 97.0 ± 4.1 |
| Ara-U (100) | 127.1 ± 5.8 |
| Ara-H (100) | 150.2 ± 16.6 |
| 5′-Deoxy-Ara-C (100) | 105.7 ± 6.0 |
| Ara-C (4) + C (20) | 72.3 ± 12.1 |
| Ara-C (4) + dC (20) | 97.1 ± 2.6 |
a
Calculated by using the following formula: (number of double-positive cells/total number of cells positive for carboxyfluorescein diacetate) × 100. To allow comparison between experiments, percentages of viral dissemination were normalized to the value obtained for the untreated cell control in each experiment. Each value given is the mean for three independent experiments ± the standard error of the mean.