TABLE 1.
Identified epitopes with 10 associated HLA and sequences
| Peptide sequencea | HLAb | Viral isolate sequencec | Defined restrictiond |
|---|---|---|---|
| LRPGGKKKYRLKHLV | A6601, A6801, B5301, B5802 | LRPGGKKKYKLKHLV | B8 (p17 24-31) |
| -------------I- | A3002, A6801, B5703, B5802 | ||
| SLYNTVATLYCVHQR | A3002, A6801, B5703, B5802 | SLFNTVATLYCVHQR | A3002, A0201, A0202, A0214 B62 (p17 77-85) |
| A0201, A2902, B1402, B1503 | |||
| QMVHQSLSPRTLNAW | A3002, A6801, B5703, B5802 | QMTHQNLSPRTLNAW | B0702, B8101 (p24 16-24) |
| A3001, A6601, B5801, B5802 | QMVHQALSPRTLNAW | ||
| TPQDLNMMLNIVGGH | A0201, A2902, B1402, B1503 | Conserved | B7, B53 (p24 48-56) |
| A0101, A7401, B5801 | |||
| FRDYVDRFYKTLRAE | A0101, A7401, B5801 | FRDYVDRFYKVLRAE | B1801, A2402, B44, B1501, B70 (p24 161-170) |
| --------F------ | |||
| MTYKGAFDLSHFLKE | A6601, A6801, B5301, B5802 | Conserved | No match (Nef 77-85) |
| A0202, A3002, B5703, B5802 | |||
| SKKRQEILDLWVYHT | A0202, A3002, B5703, B5802 | SKKRQDILDLWVYNT | No match (Nef) |
| A6801, A7401, B0702, B3501 | |||
| FPVRPOVPLRPMTYK | A0201, A0301, B4501, B5802 | Conserved | A0301, A11, B35, B51, B27 (Nef 73-82) |
a
Sequences of responding synthetic peptides. Identified epitopes previously mapped with known HLA restriction are underlined.
b
HLA A and B typing for individual responders. Underlined haplotypes are previously identified HLA-restricted epitopes.
c
Autologous sequence matching immunogenic regions with amino acids in bold type representing different amino acids than in the cognate synthetic peptide sequence.
d
Known published restricted epitopes matching exact sequences of individual synthetic peptides (http://www.hiv.lan1.gov/content/immunology/tables/ctl_summary.html, accessed August 2004). “No match” indicates lack of exact sequence match with known HLA A and B alleles.