ePVS manual counting. Examples show ePVS burden in (A) the centrum semiovale (green arrows), (B) the putamen (red arrow) and head of caudate (yellow arrow) of the basal ganglia, (C) the hippocampus (purple arrow), and the midbrain (blue arrow). T1W (D), FLAIR (E), and QSM (F) images were used to differentiate ePVS from mimics. Lacunes (yellow arrow) appear hypointense with a ring of hyperintensity on FLAIR while CMBs are hypointense areas surrounded by increased susceptibility on QSM (orange arrows, shown in different participant).