TABLE 2.
Left ventricular function in 12-week-old Rb- and p130- null micea
| CRbL/L p130+/+ | CRbL/L p130−/− | |
|---|---|---|
| VST (mm) | 0.71 ± 0.02 | 0.77 ± 0.03 |
| EDD (mm) | 3.91 ± 0.16 | 4.5 ± 0.18b |
| PWT (mm) | 0.76 ± 0.02 | 0.78 ± 0.02 |
| ESD (mm) | 2.73 ± 0.15 | 3.41 ± 0.19b |
| Ao-ET (ms) | 55.2 ± 1.5 | 57.5 ± 2.7 |
| HR (bpm) | 537 ± 26 | 444 ± 22b |
| LV% FS | 30.4 ± 1.7 | 24.3 ± 2.1b |
| Vcf (mm/s) | 5.54 ± 0.35 | 4.28 ± 0.39b |
a
Results are presented as the mean±the standard error of the mean. For definitions of abbreviations, see Table 1, footnote a. There were nine mice per group.
b
P < 0.05 by analysis of variance.