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. 2005 Mar;25(6):2191–2199. doi: 10.1128/MCB.25.6.2191-2199.2005

FIG. 3.

FIG. 3.

Functional analyses of PLCɛΔX/ΔX mouse hearts. (A) Color flow-mapping Doppler echocardiograph of the PLCɛΔX/ΔX mouse heart at the diastolic phase showing the aortic valve (AV) and the left ventricle (LV). The blue color represents that backward flow through the aortic valve reaches the apex of the left ventricle, suggesting massive aortic regurgitation. The movie clip of the color flow-mapping Doppler echocardiograph of this mouse is also available as in the supplemental data as Fig. S2. (B) Representative pulsed-wave Doppler echocardiographic images of the flow velocity across the aortic valve of PLCɛ+/+ (+/+) and PLCɛΔX/ΔX (ΔX/ΔX) mice. (C) Representatives of the measurement of withdrawal pressure across the aortic valve. Pressure measurements of 20-week-old female PLCɛ+/+ (+/+) and PLCɛΔX/ΔX (ΔX/ΔX) mice were performed by a pullback of a catheter from the left ventricular outflow tract (LVOFT) to the aorta through the aortic valve. PG, pressure gradient; AV, aortic valve; Ao, aorta.