TABLE 2.
Summary of hemodynamic analysisa
| Test or characteristic | Result for indicated PLCɛ genotype at age:
|
|||
|---|---|---|---|---|
| 8 wk
|
20 wk
|
|||
| +/+ | ΔX/ΔX | +/+ | ΔX/ΔX | |
| LVP (mm Hg) | 83 ± 6 | 95 ± 4 | 88 ± 3 | 108 ± 7* |
| EDP (mm Hg) | 3.1 ± 0.9 | 2.4 ± 0.7 | 2.0 ± 0.7 | 3.9 ± 1.0 |
| dP/dtmax (× 103 mm Hg/s) | 8.7 ± 1.0 | 7.2 ± 0.9 | 6.8 ± 0.8 | 7.1 ± 0.5 |
| dP/dtmin (× 103 mm Hg/s) | −5.7 ± 0.7 | −4.8 ± 0.5 | −6.2 ± 0.7 | −6.3 ± 0.6 |
| APmax (mm Hg) | 80 ± 6 | 72 ± 5 | 87 ± 3 | 82 ± 5 |
| APmin (mm Hg) | 38 ± 5 | 30 ± 5 | 47 ± 5 | 45 ± 6 |
| PG (mm Hg) | 3.4 ± 0.6 | 22.8 ± 4.5** | 1.2 ± 1.0 | 26.2 ± 4.0** |
| Total no. of mice analyzed | 9 | 10 | 8 | 6 |
a
Abbreviations: LVP, maximal left ventricular pressure; EDP, left ventricular end-diastolic pressure; dP/dtmax, maximal first derivative of the change in left ventricular pressure/time (pressure development); dP/dtmin, minimum first derivative of the change in left ventricular pressure/time (pressure relaxation); APmax, maximal aortic pressure; APmin, minimal aortic pressure; PG, pressure gradient across the aortic valve. *, P < 0.05; **, P < 0.01 between PLCɛ+/+ and PLCɛΔX/ΔX mice.