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. 2023 Oct 12;20(11):1379–1392. doi: 10.1038/s41423-023-01088-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Alleviated EAU inflammation after ANXA2 silencing. A Molecular function of MPP2 mutant in proteomics. B The top Ion score of the secondary spectrum of ANXA2. C The top Ion score of the secondary spectrum of EEF1A1. D Co-IP results of MPP2 to ANXA2 or EEF1A1. E The grayscale statistics of upper Co-IP results (n = 3/group; mean ± SD; NS p > 0.05, *p < 0.05; unpaired Student’s t test). F The protein level of ANXA2 in MPP2-K315 or homozygous or heterozygous MPP2-N315 knock-in mice with EAU. G Quantification of ANXA2 in the three groups mentioned above (n = 3/group; mean ± SD; NS > 0.05; one-way ANOVA). H Knockdown efficiency of ANXA2 in MPP2-K315 or MPP2-N315 knock-in mice with siANXA2 (n = 3/group; mean ± SD; ***p < 0.001; one-way ANOVA). I, J Clinical scores of MPP2-K315 or MPP2-N315 knock-in mice with or without ANXA2 silencing under immunization. White arrow, inflammatory cells. Red arrow, conjunctival and ciliary hyperemia (n = 8/group; mean ± SD; *p < 0.05; Mann–Whitney U test). K, L Histopathological scores in the four groups mentioned above. Red arrow, inflammatory cells. White arrow, retina fold (scale bar, 50 μm.) (n = 6–7/group; mean ± SD; **p < 0.01; Mann–Whitney U test). M Representative images of Evans blue in the above groups. White arrow, vessel leakage (scale bar, 10 μm)