Fig. 6.

Exacerbation of EAU inflammatory phenotypes via the MPP2/ANXA2/ERK3/IL-17E pathway. A, C The protein level and quantification of ERK3 in oeWT or oeMPP2-N315 ARPE19 cells with or without siANXA2 based on MPP2 KO (n = 3/group; mean ± SD; **p < 0.01; one-way ANOVA). B, D The expression and quantitative chart of ERK3 in MPP2-K315 or MPP2-N315 knock-in mice with scramble or siANXA2. (n = 3/group; mean ± SD; ***p < 0.001; one-way ANOVA). E The extracellular protein level of IL-17E (n = 6/group; mean ± SD; *p < 0.05, **p < 0.01; one-way ANOVA). F The secretion level of IL-17E in vivo (n = 6/group; mean ± SD; **p < 0.01; one-way ANOVA). G Schematic diagram of the MPP2-N315 mutation exacerbating EAU inflammation through the ANXA2/ERK3/IL-17E pathway