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. 2023 Oct 30;14:6902. doi: 10.1038/s41467-023-42558-y

Fig. 8. Examples of novel genes expressed in human and non-human primate embryos.

Fig. 8

A Short-read RNA-Seq expression across developmental stages (displayed in blue, RPKM normalization) and long-read-defined isoforms for evolutionarily conserved novel human gene NOVELG000067783. B, C Short-read RNA-Seq expression from macaque and marmoset preimplantation embryos (data from Wang et al. and Boroviak et al., respectively), and long-read-defined isoforms for novel human gene NOVELG000067783. Novel isoform annotations from the human genome (hg38) were lifted to the corresponding locations in the respective primate genomes (Mmul10 for macaque, calJac4 for marmoset) using liftOver. D Short-read RNA-Seq expression, long-read-defined isoforms and matching chromatin accessibility (from Liu et al.) for three novel human-specific genes. Also shown are repetitive genomic elements from RepeatMasker. Source data are provided as a Source Data file. Icons in A–D were created with BioRender.com.