Fig. 1.

Bcl-3 inhibited IL-10 production and HDM-induced allergic asthma. A Experimental scheme of HDM sensitization and challenge. Mice were sensitized with HDM (1.36 µg protein) or PBS on days 0, 1, and 2 and challenged daily from days 8–12 with 5 µg of HDM or PBS. Mice were euthanized on day 14 for analysis. B Differential cell counts in bronchoalveolar lavage fluid of PBS- or HDM-treated Bcl-3^+/+ and Bcl-3^−/− mice. C Representative lung sections stained with H&E (scale bar, 100 μm). D Cytokine levels in mouse lungs. E Levels of HDM-specific immunoglobulins in mouse sera. F Lung resistance in response to increasing doses of methacholine. Data in (B–F) were combined from four experiments; n = 6–15. B, E Student’s t test. (D) Mann‒Whitney test. F Two-way ANOVA