Fig. 2.

Bcl-3 mitigated DC/epithelial responses and IL-10 secretion during HDM sensitization. A–D Gating strategy, cell number, and activation marker CD86 in DCs in Bcl-3^+/+ and Bcl-3^−/− lungs. Mice were sensitized intranasally with HDM on days 0, 1, and 2 and analyzed on day 4. E Chemokine/cytokine concentrations in Bcl-3^+/+ and Bcl-3^−/− bronchoalveolar lavage fluid. F, G Cytokine/chemokine and Toll-like receptor signaling inhibitor mRNA levels in Bcl-3^+/+ and Bcl-3^−/− lung homogenates. E–G Mice were sensitized intranasally with HDM for 4 h. The data in (B–G) were combined from three experiments; n = 7–12. B Mann–Whitney test. C–G Student’s t test