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. 2023 Oct 30;13:18644. doi: 10.1038/s41598-023-45517-1

Table 1.

The nucleotide (nNT) mutations with the highest frequency predicted at various loci of SARS-CoV-2 genomes extracted from deceased COVID-19 patients of different countries.

Country Loci of SARS-CoV-2 genome
S ORF1a N ORF1b ORF8 ORF3a ORF9b ORF7a M ORF6 ORF7b E
Brazil D614G T1001I D3L E1264D E92K Q57H Q77E T40I L29F S41P S5L P71L
Mexico D614G A1708D R203K P314L R52I P42L P10S D36Y A104V S43P T40I T30I
USA D614G I2230T D3L P218L Y73C Q57H P10S A43S T175M E13D T40I P71L
India D614G T1001I G204R K1383R R52I P42L Q77E N38T L87F I14T S5L T9I
Iran D614G I2230T R203K E1264D E92K Q57H P10S T40I A69S P57L E33A P71S
Spain N501Y T1001I G204R P218L R52I S253P R32L M1K V70F K42N H42Y V49L
China D614G T1001I P80R E1264D E92K P42L Q77E A15S A69S S41P S5L R69G
UK D614G A1708D R203K K1383R E92K Q57H R32L S5L L29F W27L T40I T30I
France D614G I2230T G204R P218L R52I P42L T60A A15S S4F D61L S5L P71L
Italy N501Y T1001I S235F K1383R E92K S253P P10S V21F H125Y L4V T40I T30I
Japan D614G A1708D P80R P314L Y73C Q57H Q77E S5L L29F S41P S5L T30I
Germany D614G T1001I G204R P314L Y73C S253P P10S S5L T175M S43P T40I T30I
Highest D614G T1001I G204R E1264D, P314L E92K Q57H Q77E S5L L29F S41P T40I P71L