Table 3.
Total Heart Failure Event Rates by FGF23 Quartile
| Total N = 3,879 Events |
Overall Rate | Rate Ratio (95% CI) |
||||
|---|---|---|---|---|---|---|
| FGF23 Q1 n = 970 | FGF23 Q2 n = 970 | FGF23 Q3 n = 970 | FGF23 Q4 n =969 | |||
| N, Events | 3,879 (2,386) | 2,386 | 312 | 506 | 596 | 972 |
| Crude ratea | 3,879 (2,386) | 5.49 (4.98-6.01) | 2.52 (1.92-3.12) | 4.32 (3.35-5.29) | 5.63 (4.67-6.59) | 11.10 (9.49-12.72) |
| Unadjusted | 3879 (2,386) | 1.90 (1.72-2.11) | 1.0 (Ref) | 1.71 (1.23-2.37) | 2.22 (1.66-2.98) | 4.39 (3.32-5.80) |
| Model 1 | 3,879 (2,386) | 2.00 (1.80-2.22) | 1.0 (Ref) | 1.62 (1.17-2.25) | 2.21 (1.64-2.98) | 4.31 (3.24-5.72) |
| Model 2 | 3,695 (2,256) | 1.76 (1.55-1.99) | 1.0 (Ref) | 1.43 (1.02-2.01) | 1.61 (1.17-2.23) | 2.85 (2.05-3.96) |
| Model 3 | 3,561 (2,164) | 1.57 (1.36-1.81) | 1.0 (Ref) | 1.26 (0.89-1.78) | 1.15 (0.82-1.62) | 1.90 (1.36-2.66) |
| Model 4 | 3,404 (2,079) | 1.55 (1.33-1.80) | 1.0 (Ref) | 1.25 (0.88-1.78) | 1.12 (0.79-1.60) | 1.81 (1.28-2.57) |
Note: Model 1: adjusted for age, sex, race, ethnicity, and study site (N = 3,879); Model 2: Model 1 plus estimated glomerular filtration rate, and 24H urine protein (n = 3,695 owing to missing covariates); Model 3: Model 2 plus BMI, diabetes, smoking, systolic blood pressure, any cardiovascular disease, total cholesterol, statins, number of blood pressure medications, phosphate, and parathyroid hormone. (n = 3,561 owing to missing covariates); Model 4: Model 3 plus calcium, CRP (log-transformed), TSAT, and ferritin (log-transformed).
Abbreviation: FGF23, fibroblast growth factor 23.
Crude rates are reported as rate per 100 patient years (95% CI). Overall rates are reported as event rate per 100 patient year increase per unit increase in natural log of FGF23 (95% CI).