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RPE synthesizes and export amino acids to the retina using nitrogen from proline. RPE uptakes and catabolizes proline through PRODH to produce P5C, which can be converted into ornithine, glutamate, and multiple amino acids. All these amino acids can be exported to be utilized by the neural retina. P5C, pyrroline-5-carboxylate; PRODH, proline dehydrogenase; RPE, retinal pigment epithelium.
