Article | Outcome definition | Time point | Nedocromil sodium or sodium cromoglycate | Placebo | Number of participants randomised (n) and comments |
Davies 1993 | Participants’ global evaluation of treatment efficacy (4‐point scale) | 28 days | Cromoglycate: Excellent/good: 68% Moderate/poor: 32% |
Excellent/good: 63% Moderate/poor: 37% |
n = 95 Individual categories may be estimated from graph, and mean score could be calculated if considered appropriate |
James 2003 | Investigator’s composite symptom score (itching, tearing, conjunctival redness) (range 0‐9), participant’s composite symptom score (itching, redness, tearing) (range 0‐9) | 14 days | Cromoglycate: Investigator: Mean 2.2 Participant: Mean 1.8 |
Investigator: Mean 2.9 Participant: Mean 2.8 |
n = 144 Estimated from graph (no SD). Days 3 and 7 also available (investigator‐reported); days 1‐14 available (participant‐reported) |
Leino 1992 | Overall assessment by participants and investigators (4‐point scale) | 28 days | Cromoglycate and nedocromil: No data presented |
No data presented | n = 195 No significant differences between the 3 groups (except for subgroup analysis by centre) |
Melamed 1994 | Participant‐reported composite symptom score: itchy eyes, burning eyes, tearing eyes, overall eye condition (range 0‐16) | 14 days | Nedocromil: Mean 3.8 |
Mean 5.1 | n = 86 No SD. Estimated from graph in Figure 2 of the original report. Slightly unclear which symptoms contributed to this score |
Melamed 2000 | Participant‐reported composite symptom score: itchy eyes, burning eyes, tearing eyes, overall eye condition (range 0‐16) | "peak pollen period" | Nedocromil: Mean 3.95 |
Mean 4.92 | n = 189 No SD. The time point varied by included study. One of the two studies is Melamed 1994, above |