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. 2015 Jun 1;2015(6):CD009566. doi: 10.1002/14651858.CD009566.pub2
Article Outcome definition Time point Nedocromil sodium or sodium cromoglycate Placebo Number of participants randomised (n) and comments
Davies 1993 Participants’ global evaluation of treatment efficacy (4‐point scale) 28 days Cromoglycate:
Excellent/good: 68%
Moderate/poor: 32%
Excellent/good: 63%
Moderate/poor: 37%
n = 95
Individual categories may be estimated from graph, and mean score could be calculated if considered appropriate
James 2003 Investigator’s composite symptom score (itching, tearing, conjunctival redness) (range 0‐9), participant’s composite symptom score (itching, redness, tearing) (range 0‐9) 14 days Cromoglycate:
Investigator: Mean 2.2
Participant: Mean 1.8
Investigator: Mean 2.9
Participant: Mean 2.8
n = 144
Estimated from graph (no SD). Days 3 and 7 also available (investigator‐reported); days 1‐14 available (participant‐reported)
Leino 1992 Overall assessment by participants and investigators (4‐point scale) 28 days Cromoglycate and nedocromil:
No data presented
No data presented n = 195
No significant differences between the 3 groups (except for subgroup analysis by centre)
Melamed 1994 Participant‐reported composite symptom score: itchy eyes, burning eyes, tearing eyes, overall eye condition (range 0‐16) 14 days Nedocromil:
Mean 3.8
Mean 5.1 n = 86
No SD. Estimated from graph in Figure 2 of the original report. Slightly unclear which symptoms contributed to this score
Melamed 2000 Participant‐reported composite symptom score: itchy eyes, burning eyes, tearing eyes, overall eye condition (range 0‐16) "peak pollen period" Nedocromil:
Mean 3.95
Mean 4.92 n = 189
No SD. The time point varied by included study. One of the two studies is Melamed 1994, above