Article	Outcome definition	Time point	Olopatadine	Ketotifen	Number of participants randomised (n) and comment
Avunduk 2005	Participant‐reported (itching and tearing; range 0‐3) and ocular signs (redness, eyelid swelling, chemosis; range 0‐3)	15 days	Itching: Mean (SD) 0.76 (0.1) Tearing: Mean (SD) 0.30 (0.1)	Itching: Mean (SD) 1.08 (0.2) Tearing: Mean (SD) 0.17 (0.1)	n = 39 SD estimated from graph
Höffling‐Lima 2001	Participant‐reported (itching, burning, watering, discharge, photophobia; range 0‐3) Signs, investigator examination (range 0‐3)	14 days	Itching: Mean 0.50 Watering: Mean 0.15 Burning: Mean 0.18 Photophobia: Mean 0.00	Itching: Mean 0.55 Watering: Mean 0.11 Burning: Mean 0.11 Photophobia: Mean 0.05	n = 40
Sarker 2011	Participant‐reported (itching, watering, photophobia; range 0‐3) (redness; range 0‐3)	14 days	Itching: Mean (SD): 0.33 (0.60) Watering: Mean (SD): 0.03 (0.15) Photophobia: Mean (SD): 0.05 (0.22)	Itching: Mean (SD): 1.09 (0.52) Watering: Mean (SD): 0.40 (0.66) Photophobia: Mean (SD): 0.26 (0.44)	n = 92
Varguez‐Rodriguez 2009	Participant‐reported (itching, watering, burning; range 0‐3) Signs, investigator examination (redness, chemosis; range: present or absent)	14 days	Data not extractable. Only P value available.	Data not extractable. Only P value available.	n = 40 Olopatadine induced greater reduction of burning than ketotifen at 2 weeks. There was no difference in itching and tearing at 2 weeks