Davies 1993.
Methods | Parallel‐group RCT | |
Participants | 95 participants recruited with allergic conjunctivitis | |
Interventions | Three treatment arms: levocabastine 0.5 mg/ml; sodium cromoglycate 20 mg/ml; placebo eye drops. Duration of treatment 28 days | |
Outcomes | Investigators' and participants' assessment of ocular symptoms (4‐point qualitative scale: excellent, good, moderate, poor) Time points: at baseline, day 14 and 28 after treatment |
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Country | United Kingdom | |
Number randomised, gender (male:female) | 95 participants randomised. M:F 40:49 | |
Age mean (SD), median, range | Mean (range) levocabastine 30 years (7‐66); sodium cromoglycate 31 years (10‐69); placebo 30 years (13‐61) | |
Notes | Not reported when study was conducted. Source of funding not stated. Declaration of interest by the authors was not stated | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | The method used to generate the allocation sequence was not described. |
Allocation concealment (selection bias) | Unclear risk | The method used to conceal the allocation sequence was not described. |
Incomplete outcome data (attrition bias) All outcomes | High risk | Percentages given (numerators/denominators unclear) |
Selective reporting (reporting bias) | High risk | P values given for selected outcomes |
Other bias | Unclear risk | No apparent evidence of other risk of bias |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Double‐masked (p.520 ‐ methods): "…95 patients participated in this double‐blind, parallel group trial." |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Double‐masked (p.520 ‐ methods): "…95 patients participated in this double‐blind, parallel group trial." |