Lanier 2001.

Methods	Parallel‐group RCT
Participants	94 participants with seasonal allergic conjunctivitis
Interventions	Two treatment arms: olopatadine and oral loratadine; oral loratadine. Duration of treatment 1 week
Outcomes	Participants' and physicians' assessment of ocular signs and symptoms Mean scores for ocular itching and redness using diaries and a 4‐point scale Time points: at baseline, day 3 and 7 after treatment
Country	United States
Number randomised, gender (male:female)	94 participants randomised, 72 participants analysed. M:F 33:61
Age mean (SD), median, range	Mean (range): olopatadine and oral loratadine 39 years (7‐74); oral loratadine 37 years (9‐74)
Notes	Study conducted from May to November 1998. Source of funding Alcon Pharmaceutical. Declaration of interest by the authors was not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	The method used to generate the allocation sequence was not described
Allocation concealment (selection bias)	Unclear risk	The method used to conceal the allocation sequence was not described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Exclusion of 22 participants after randomisation (p.644 ‐ results): "Ten patients were not evaluable for efficacy because they did not meet inclusion/exclusion criteria or had no follow up examination... Twelve patients exited the study prematurely..."
Selective reporting (reporting bias)	Low risk	Evidence was available of proper outcome reporting
Other bias	Low risk	No apparent evidence of other risk of bias
Blinding of participants and personnel (performance bias) All outcomes	High risk	(p.643 ‐ study design): "Because there were no control eye drops, patients were aware of their treatment groups, but clinicians performing the evaluations in the clinic were not."
Blinding of outcome assessment (detection bias) All outcomes	High risk	(p.643 ‐ study design): "Because there were no control eye drops, patients were aware of their treatment groups, but clinicians performing the evaluations in the clinic were not."